>Function
>1|P43463|HTH-type transcriptional activator aarP|Providencia stuartii|AraC
AarP activates the gene encoding 2'-N-acetyltransferase, capable of acetylating both peptidoglycan and certain aminoglycoside antibiotics. Introduction of AarP on a multicopy plasmid confers a Mar phenotype with higher resistance levels to tetracycline, chloramphenicol and ciprofloxacin.
>2|P34000|HTH-type transcriptional regulator acrR (Potential acrAB operon repressor)|Escherichia coli O6|TetR
AcrR represses its own expression.
AcrR represses the expression of the acrAB operon.
The expression of the gene micF could be under the AcrR control.
>4|P19219|Methylphosphotriester-DNA alkyltransferase|Bacillus subtilis|AraC
In Bacillus subtilis, the adaptive response to DNA alkylation depends on the ada operon, which consists of the adaA and adaB genes. The AdaA protein is a methylphosphotriester DNA methyltransferase and it is a transcriptional activator of the ada operon.
>5|P06134|ADA regulatory protein (Regulatory protein of adaptative response) [Contains: Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (O-6-methylguanine-DNA alkyltransferase)]|Escherichia coli|AraC
The ada gene product has both repair and regulatory activities. It acts as an enzyme repairing alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. It can also repair O-4 methylthymine.
Cys 321 is the methyl acceptor site required for the removal of the methyl groups from O-6-methyl-guanine and O-4-methylthymine, two highly mutagenic lesions.
Cys 79 is required for demethylation of phosphometyltriesters in the sugar phosphate backbone. Although methylated phosphates are innocuous, this lesion is readily produced for methylating agents and provides a sensitive regulatory signal that leads to the induction of Ada regulon. Once Ada has a methylated Cys-69 it becomes a transcriptional activator. This function resides in its N-terminus.
>6|Q10630|Putative ADA regulatory protein (Regulatory protein of adaptative response) [Contains: Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (O-6-methylguanine-DNA alkyltransferase)]|Mycobacterium tuberculosis|AraC
It acts as an enzyme repairing alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme.
This is a suicide reaction: the enzyme is irreversibly inactivated.
It can also repair O-4 methylthymine. The methylated Ada protein acts as a positive transcription regulator. This function resides in its N-terminus.
>7|P26189|ADA regulatory protein (Regulatory protein of adaptative response) [Contains: Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (O-6-methylguanine-DNA alkyltransferase)]|Salmonella typhimurium|AraC
Ada serves as a positive regulator of the adaptive response to alkylating agents, and as a DNA repair enzyme. Ada has major effects on tolerance to organic acid stress but only minor effects on inorganic acid stress.
>9|Q9ZN78|A-factor receptor protein (A-factor binding protein)|Streptomyces griseus|TetR
ArpA acts as a repressor of the streptomycin production and sporulation.
Streptomycin biosynthesis as well as differentiation in Streptomyces griseus is absolutely dependent on the autoinducer A-factor, acting via an A-factor receptor protein (ArpA).
ArpA regulates, repressing, the expression of apdA.
The adpA product is a positive transcriptional regulator belonging to the AraC/XylS family.
AdpA control the AdpA activates the expression of strR.
StrR protein activates the expression of streptomycin biosynthetic genes.
A-factor and its specific receptor protein ArpA control streptomycin production, streptomycin resistance, and aerial mycelium formation in Streptomyces griseus.
>10|P43464|Transcriptional activator aggR (AAF/I regulatory protein)|Escherichia coli|AraC
Transcriptional activator of aggregative adherence fimbria I expression in enteroaggregative Escherichia coli strains. AggR regulates transcription of aafA and aafD in AAF/II region 1. AggR apparently acts directly to regulate the aafD promoter; however, the role of AggR in aafA transcription is not clear.
>13|P05052|HTH-type transcriptional regulator appY (M5 polypeptide)|Escherichia coli|AraC
AppY activates transcription of the hydrogenase 1 operon and of the acid phosphatase operon during anaerobic growth.
>14|P11765|Arabinose operon regulatory protein|Citrobacter freundii|AraC
This protein controls the expression of at least six genes involved in the transport and catabolism of L-arabinose.
>15|P03021|Arabinose operon regulatory protein|Escherichia coli O157:H7|AraC
AraC controls the expression of genes involved in the transport and catabolism of L-arabinose.
>16|P07642|Arabinose operon regulatory protein|Erwinia chrysanthemi|AraC
This protein controls the expression of at least six genes involved in the transport and catabolism of L-arabinose.
>17|P03022|Arabinose operon regulatory protein|Salmonella typhimurium|AraC
This protein controls the expression of at least six genes involved in the transport and catabolism of L-arabinose.
>25|P17446|HTH-type transcriptional regulator betI|Escherichia coli|TetR
BetI is a choline-sensing repressor of the bet regulon.
It represses both promoters simultaneously, the betT and the betIBA promoters, impeding the expression of the bet genes involved in osmotic stress resistance.
>35|P43506|HTH-type transcriptional repressor Bm3R1|Bacillus megaterium|TetR
Bm3R1 is a transcriptional repressor implicated in the regulation of barbiturate-inducible proteins in Bacillus megaterium.
>37|P26950|F1 operon positive regulatory protein|Yersinia pestis|AraC
Positive regulator of the expression of the F1 operon.
>38|P25393|CFA/I fimbrial subunit D (Colonization factor antigen I subunit D)|Escherichia coli|AraC
The function of the CfaD protein is to overcome the repression mediated by the histone-like H-NS protein on the promoter in front of the cfaA gene at the CFA/I region.
>39|P17410|HTH-type transcriptional regulator chbR (Chb operon repressor)|Escherichia coli|AraC
N,N'-diaacetylchitobiose (GlcNaC)2 catabolism and uptake.
>40|P43460|HTH-type transcriptional activator csvR|Escherichia coli|AraC
Transcriptional activator of the fimbrial gene in enterotoxigenic Escherichia coli strains. The level of expression of CFA/I fimbriae induced by CsvR is not as high as when expression is induced by CfaD or Rns.
>42|P10805|Porin thermoregulatory protein envY|Escherichia coli|AraC
EnvY induces the temperature-dependent expression of several Escherichia coli envelope proteins, most notably porins OmpF and OmpC, as well as the lambda receptor LamB.
>43|P36547|HTH-type transcriptional regulator eutR (Ethanolamine operon regulatory protein)|Escherichia coli|AraC
EutR activates the transcription of the eut operon.
>44|Q9ZFU7|HTH-type transcriptional regulator eutR (Ethanolamine operon regulatory protein)|Salmonella typhimurium|AraC
EutR activates the transcription of the Eut operon. It also positively regulates its own transcription. It probably binds ethanolamine and vitamin B12 as effectors.
>45|P26993|Exoenzyme S synthesis regulatory protein exsA|Pseudomonas aeruginosa|AraC
It regulates a series of operons encoding proteins involved in the infection of eukaryotic cells by a process generally referred to as type III secretion or polarized translocation. Type III secretion and infection in P. aeruginosa are encoded by three types of gene products that include components of a secretory apparatus (ExsD, PscB-L, and PscN-U), proteins mediating the translocation of effectors into the host cell cytoplasm (PopB and PopD), and effector proteins (ExoS, ExoT, ExoU and ExoY) that are postulated to disrupt normal cellular processes.
Type III-mediated effector translocation is postulated to inhibit the phagocytic response to infection, allow bacterial replication, and promote epithelial injury.
ExoS is an ADP-ribosyltransferase. Host target proteins modified by ExoS include members of the H- and K-Ras family of proteins, vimentin, the Fc region of IgG3, and apolipoprotein A1. Of these targets, ADP-ribosylation of Ras has been correlated to the uncoupling of Ras-mediated signal transduction in PC-12 neuronal cells.
ExoU expression is correlated with acute cytotoxicity and lung damage, but the role of ExoT remains elusive.
ExoY is an extracellular adenylate cyclase.
>46|P23774|987P fimbrial operon positive regulatory protein fapR|Escherichia coli|AraC
FapR is a positive regulator of the expression of the 987P operon for the fimbrial protein in enterotoxigenic Escherichia coli.
>47|Q47129|Transcriptional activator feaR|Escherichia coli|AraC
Positive regulator of the tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism.
>60|P41782|Transcriptional regulator hilD|Salmonella typhimurium|AraC
HilD participates in the regulation of HilA.
>61|P31778|Regulatory protein hrpB|Ralstonia solanacearum|AraC
HrpB is a positive regulator of hypersensitive response genes involved in plant pathogenicity and partly in its own synthesis in minimal medium.
>64|P39437|Invasion protein invF|Salmonella typhimurium|AraC
InvF acts as a regulator of the invasion operon. InvF is required for the optimal expression of several genes encoding SPI (Salmonella pathogenicity island) secreted proteins.
>69|O33813|Lactose operon transcription activator|Staphylococcus xylosus|AraC
Transcriptional regulator of the lacPH genes for lactose utilization.
The lactose utilization system of Staphylococcus xylosus is made up of two structural genes, lacP and lacH, which encode the lactose permease and the beta-galactosidase proteins, respectively, and a regulatory gene, lacR, coding for an activator.
>70|P28808|Thermoregulatory protein lcrF|Yersinia pestis|AraC
Transcriptional activator of the thermally-regulated virulent yopE gene. LcrF activity could be modulated by the interaction with an inducer molecule serving as a temperature messenger. The availability of the messenger would in turn be controlled by a temperature-responsive process serving as a cellular thermometer.
>71|Q51872|Probable transcriptional regulator lumQ|Photobacterium leiognathi|AraC
Probable transcriptional regulator, although target regulated gene(s) is(are) not yet known.
>72|P21308|HTH-type transcriptional regulator luxR|Vibrio harveyi|TetR
LuxR is required for the expression of luxCDABEGH (luciferase) operon, responsible of luminiscence in this strain.
The luminescence system also may be used as a terminal oxidase when the cytochrome electron transport system cannot be synthetized (for example, low iron availability) or does not function due to low oxygen tension.
LuxR seems to have other regulatory functions, suggesting that LuxR is a general regulatory protein.
LuxR may be necesary for the Vibrio harveyi rugose phenotype.
The LuxR homolog of Vibrio parahemolyticus, OpaR, is involved in the switch to the opaque phenotype.
LuxR from Vibrio harveyi controls the synthesis of PHA (specifically poly-3-hydroxibutyrate) is.
>73|P27246|Multiple antibiotic resistance protein marA|Escherichia coli O157:H7|AraC
The MarA protein controls the expression of multiple chromosomal genes affecting resistance to antibiotics, organic solvents, oxidative stress agents, disinfectant products and other environmental hazards.
>75|Q56070|Multiple antibiotic resistance protein marA|Salmonella typhimurium|AraC
MarA of Escherichia coli and MarA of Salmonella typhimurium are interchangeable between organisms. MarA of Salmonella typhimurium is a transcriptional activator of the genes involved in the multiple-antibiotic-resistance (mar) phenotype.
>78|P10411|Melibiose operon regulatory protein|Escherichia coli O6|AraC
MelR activates the transcription of the melA and melB genes, cotranscribed from a single promoter, in response to the presence of melibiose in the growth medium. MelR regulates the pathway for the degradation of melibiose.
>80|P28809|MmsAB operon regulatory protein|Pseudomonas aeruginosa|AraC
Transcriptional activator of the mmsAB operon for valine catabolism.
>81|Q00753|Msm operon regulatory protein|Streptococcus mutans|AraC
Regulatory protein for the msm operon for the metabolism multiple sugars. MsmR activates the transcription of the msmEFGK, aga, dexB and gftA genes. This system is responsible for the uptake of melibiose, raffinose, and isomaltotriose and for the metabolism of melibiose, sucrose, and isomaltosaccharides.
>82|P39897|HTH-type transcriptional regulator mtrR|Neisseria gonorrhoeae|TetR
MtrR is a transcriptional repressor that regulates transcription of the mtrCDE genes.
MtrR might act directly or indirectly as a positive regulator of farAB gene expression.
>83|Q04642|Transcriptional regulator mxiE|Shigella flexneri|AraC
MxiE is necessary for the secretion of lpa invasins. Probable transcriptional regulatory protein.
>86|Q04642|Transcriptional regulator mxiE|Shigella sonnei|AraC
Possible transcriptional regulatory protein needed for the secretion of ipa invasins.
>90|P72171|Ornithine utilization regulator|Pseudomonas aeruginosa|AraC
OruR participates in the regulation of ornithine utilisation, although its mode of action is not well understood yet.
>93|P40883|Regulatory protein pchR|Pseudomonas aeruginosa|AraC
PchR is required for the production of the FptA ferric pyochelin receptor in response to iron limitation and to pyochelin.
>94|P43459|Transcriptional activator perA|Escherichia coli O127:H6|AraC
PerA probably also activates the transcription of eaeA in enteropathogenic Escherichia coli.
>97|Q05587|Regulatory protein pocR|Salmonella typhimurium|AraC
Positive regulatory protein of pdu (glycerol and propanediol utilisation) and cob (cobalamine synthesis) operons.
>98|Q52620|Regulatory protein pqrA|Proteus vulgaris|AraC
Probably confers multidrug resistance in a way similar to that of the SoxS and MarA genes.
>100|P23217|HTH-type transcriptional regulator qacR|Staphylococcus aureus subsp. aureus Mu50|TetR
QacR is a trans-acting repressor of qacA transcription that does not autoregulate its own expression.
QacA protein is a multidrug exporter that confers resistance to a wide array of monovalent or divalent cationic, lipophilic, antimicrobial compounds.
>105|P43465|Raffinose operon transcriptional regulatory protein rafR|Pediococcus pentosaceus|AraC
RafR is involved in the regulation of the raffinose-operon.
>106|P55922|Transcriptional activator ramA|Enterobacter cloacae|AraC
RamA is probably a transcriptional activator.
>107|Q48413|Transcriptional activator ramA|Klebsiella pneumoniae|AraC
Probable transcriptional activator that confers a multidrug-resistance phenotype.
>108|P09378|L-rhamnose operon transcriptional activator rhaR|Escherichia coli|AraC
RharR activates transcription of RhaS which is the activator of the L-rhamnose operon.
>110|P09377|L-rhamnose operon regulatory protein rhaS|Escherichia coli|AraC
RhaS activates transcription of the rhaBAD and rhaT operons in response to L-rhamnose.
>111|P27029|L-rhamnose operon regulatory protein rhaS|Salmonella typhimurium|AraC
Positive activator of genes required for l-rhamnose utilization and probably of for the rhamnose transporter gene rhaT.
>113|Q9Z3Q6|Transcriptional activator rhrA|Sinorhizobium meliloti|AraC
Transcriptional activator of the rhizobactin regulon.
>114|P16114|Regulatory protein rns|Escherichia coli|AraC
Rns activates transcription of the genes encoding CS1 and CS2 fimbriae.
>115|P27292|Right origin-binding protein|Escherichia coli O157:H7|AraC
Overexpression of Rob causes antibiotic resistance, organic solvent tolerance and heavy-metal resistance, whereas the deletion of Rob increases susceptibility to organic solvents.
Rob binds to the right arm of the replication origin oriC of the E. coli chromosome.
Rob binding may influence the formation of nucleoprotein structure required for oriC function at the beginning of replication.
>118|Q9R3W3|Transcriptional regulator sirC|Salmonella typhimurium|AraC
Expression of sprA from an inducible heterologous promoter increases expression of the genes associated with the centisome 63 type III secretion system and improves the ability of S. typhimurium to enter into host cells.
SirC is an SPI1-encoded transcription factor that contributes to the invasive phenotype.
>120|P22539|Regulatory protein soxS|Escherichia coli O157:H7|AraC
The genetic response in Escherichia coli to nitric oxide or to superoxide-generating agents such as paraquat is controlled by the soxRS locus. The intracellular redox signals generated by these agents are sensed by the SoxR protein which, when activated, functions as a potent activator of soxS transcription.
>121|Q56143|Regulatory protein soxS|Salmonella typhimurium|AraC
SoxS, is necessary for resistance to oxidative stress. The S. enterica serovar Typhimurium soxRS system also mediates redox-inducible resistance to diverse antibiotics.
>122|P39885|HTH-type transcriptional regulator tcmR (Tetracenomycin C transcriptional repressor)|Streptomyces glaucescens|TetR
TcmR is a regulator of the tetracenomycin C resistance. In absence of tetracenomycin C TcmR represses tcmA and tcmR expression. The presence of tetracenomycin C reduces the TcmR DNA-binding ability inducing the TcmR expression and the tetracenomycin C export pump TcmA synthesis.
>123|P29492|TCP pilus virulence regulatory protein|Vibrio cholerae|AraC
ToxT (TcpN) is a transcriptional activator of the tcp gene cluster associated with the biosynthesis and assembly of the toxin-coregulated pilus of Vibrio cholerae.
>124|P03038|Tetracycline repressor protein class A from transposon 1721|Escherichia coli|TetR
The Tn1721 TetR regulates transcription of the tetracycline resistance determinant in transposon Tn1721.
The tetracycline resistance determinant in transposon Tn1721 consists of two genes, tetA and tetR, wich are oriented with divergently polarity.
TetR is a tetracycline inducible regulator that represses the expression of both genes, tetR and tetA.
>126|P04483|Tetracycline repressor protein class B from transposon Tn10|Escherichia coli|TetR
The Tn10 TetR regulates transcription of the tetracycline resistance determinant in transposon Tn10.
The tetracycline resistance determinant in transposon Tn10 consists of two genes, tetA and tetR, wich are oriented with divergently polarity.
TetR is a tetracycline inducible regulator that represses the expression of both genes tetR and tetA.
>127|P03039|Tetracycline repressor protein class C|Escherichia coli|TetR
The pSC101 TetR, TetR(C), regulates transcription of the tetracycline resistance determinant in plasmid pSC101.
The tetracycline resistance determinant in plasmid pSC101 consists of two genes, tetA and tetR, wich are oriented with divergently polarity.
TetR is a tetracycline inducible regulator that represses the expression of both genes tetR and tetA.
>128|P09164|Tetracycline repressor protein class D|Escherichia coli|TetR
The pIP173 TetR, TetR(D), regulates transcription of the tetracycline resistance determinant in plasmid pIP173.
The tetracycline resistance determinant in plasmid pIP173 consists of two genes, tetA and tetR, wich are oriented with divergently polarity.
TetR is a tetracycline inducible regulator that represses the expression of both genes, tetR and tetA.
>138|P43462|Probable thc operon regulatory protein|Rhodococcus erythropolis|AraC
ThcR regulates the expression of thcB, the structural gene for the P-450 monooxygenase.
The cytocrome P-450 system participates in the degradation of thiocarbamates and other pesticides.
>145|P32326|Urease operon transcriptional activator|Escherichia coli|AraC
Positive regulator of the urease operon.
>146|Q02458|Urease operon transcriptional activator|Proteus mirabilis|AraC
UreR is a positive regulator of the expression of the urease operon.
In the presence of urea, UreR promotes transcription of genes required for the synthesis of urease structural and accessory proteins. The respective polypeptides make up the urease apoenzyme and are responsible for nickel incorporation into the apoenzyme to produce active holoenzyme.
>151|Q04248|Virulence regulon transcriptional activator virF|Shigella dysenteriae|AraC
VirF is required to initiate a cascade of events resulting in activation of several operons encoding invasion functions.
>162|Q06861|Possible virulence-regulating 38 kDa protein|Mycobacterium tuberculosis|AraC
Possible role in the regulation of proteins necessary for virulence.
>164|P37390|Xylose operon regulatory protein|Escherichia coli O157:H7|AraC
Regulatory protein for the xylBAFGHR operon.
>165|P45043|Xylose operon regulatory protein|Haemophilus influenzae|AraC
XylR probably regulates the xylBAFGHR operon.
>166|P07859|XylDLEGF operon transcriptional activator|Pseudomonas putida|AraC
Regulatory protein of the TOL plasmid xyl operons. XylS activates the xylXYZLTEGFJQKIH operon required for benzoate, m-toluate and p-toluate degradation.
>167|Q04710|XylDLEGF operon transcriptional activator 1|Pseudomonas putida|AraC
Regulatory protein of the TOL plasmid pWW53 meta-1 and meta-2 p-TOLUATE.
>169|Q05092|XYLDLEGF operon transcriptional activator 2|Pseudomonas putida|AraC
XylS2 is a nonfunctional gene that is truncated by an insertion sequence.
>170|Q05335|XYLDLEGF operon transcriptional activator 3|Pseudomonas putida|AraC
XylS3 activates meta-1 and meta-2 operons required for the degradation of 3-methylbenzoate by Pseudomonas (pWW53).
>172|P55449|Putative HTH-type transcriptional regulator y4fK|Rhizobium sp. NGR234|AraC
Y4FK acts probably as a transcriptional regulator in the complex cascade regulation of the Rhizobium sp. nodD3 gene.
>188|P43461|Putative HTH-type transcriptional regulator in cgkA 5'region (Fragment)|Pseudoalteromonas carrageenovora|AraC
Ycgk probably regulates the cgkA gene encoding a hydrolase involved in the degradation of kappa-carrageenan.
>245|O24739|BarB|Streptomyces virginiae|TetR
BarB could be the second step in the signal transduction pathway of the VB  autoinduce leading to virginiamycin production.
>248|O30343|Hemagglutinin/protease regulatory protein|Vibrio cholerae|TetR
HapR is a transcriptional regulator that has a central role in the control of the virulence of Vibrio cholerae, in a cell-density dependent manner.
HapR represses the expression of the virulence regulon. The virulence regulon possesses more than 20 genes involved in colonization, toxin production and bacterial survival.
HapR is absolutely required for expressing the HA protease in Vibrio cholerae. It has been postulated that HA protease is implicated in the virulence (can nick and activate the A subunit of cholera toxin) and dissemination (mediates detachment of the vibrios from host cell surfaces) of the Vibrio cholerae cells.
HapR directly or indirectly represses polysaccharide production which has been associated with the colony morphology.
>253|O33453|CymR|Pseudomonas putida|TetR
CymR is the regulatory protein that represses expression of both the cym and the cmt adjacent operons.
>255|O51847|Regulatory protein|Pseudomonas putida|AraC
IpbR probably activates the isopropylbenzene (ipb) catabolic operon.
>256|O52558|RifQ|Amycolatopsis mediterranei|TetR
RifQ represses the expression of the rifP gene that encodes the riphamycin efflux pump.
>258|O52834|AlcR (Alcaligin siderophore system regulator)|Bordetella bronchiseptica|AraC
AlcR is involved in the regulation of Bordetella alcaligin biosynthesis and transport genes, and it is required for their full expression.
>259|O52846|XylS/AraC transcriptional regulator|Bacillus megaterium|AraC
Positive transcriptional regulation of lactose utilization gene bgaM.
>262|O68276|Putative DNA-binding protein Bm1P1|Bacillus megaterium|TetR
bm1P1 negatively affected the basal-level of expression of P450BM-1.
Bm1P1 is a 217 amino acids protein and its control over expression of P450BM-1 is not mediated by barbiturates.
>263|O68442|Regulatory protein|Agrobacterium tumefaciens|TetR
The functional role of ifeR is unknown.
IfeR seems to be a repressor that controls the expression of the putative ifeABR efflux system.
>267|O69047|Putative XylS/AraC transcriptional activator (Fragment)|Salmonella typhimurium|AraC
The gene encoding this protein is adjacent to the foxA gene, whose product is involved in the utilization of ferrioxamines B, E, and G. Transport of all three ferric siderophores across the outer membrane is dependent on the FoxA receptor encoded by the Fur-repressible foxA gene. Mutants in the foxA gene are not able to use any of the three ferrioxamines.
>269|O70020|IcaR|Staphylococcus epidermidis|TetR
IcaR is a repressor of the ica operon.
>271|O85815|Putative regulatory protein|Pseudomonas sp. IC|AraC
Putative regulator of the meta-pathway operon for biphenyl/methylbiphenyl metabolism.
>278|P72185|Repressor protein|Propionibacterium freudenreichii|TetR
The product of the hemR gene might act as a transcriptional repressor involved in the expression of hemX that seems to be implicated in antibiotic resistance.
>291|Q8KLP4|Repressor|Stenotrophomonas maltophilia|TetR
SmeT represses the expression of the operon smeDEF.
>296|Q8KNI9|CalR1|Micromonospora echinospora|TetR
calR1 is one of the nine putative regulatory elements in the calicheamicin locus from Micromonospora echinospora.
>310|Q8KX64|Luminescence regulator LitR|Vibrio fischeri|TetR
litR is important for the normal induction of luminescence in Vibrio fischeri.
litR plays a positve role in modulating the ability of Vibrio fischeri to colonize juvenile squid.
It seems that litR may control the opacity/translucent phenotype of the colony in Vibrio fischeri.
It is probably that litR, opaR, hapR and scmR control the opacity/translucent phenotype of the colony.
It seems that litR does not affect protease production in Vibrio fischeri.
>328|Q8VQC6|VanT|Listonella anguillarum|TetR
VanT positively regulates serine, metalloprotease, pigment and biofilm production.
VanT seems not to be essential for virulence.
>335|Q8VVJ2|TetR protein|Corynebacterium glutamicum|TetR
The tetR(33) product represses the expression of the gene tetA(33).
>368|Q93M20|Putative transcriptional regulator|Streptomyces aureofaciens|TetR
Because of its situation in the aur1 gene cluster, aur1B could be involved, as repressor, in the biosynthesis of the polyketide auricin.
>377|Q93QZ7|HydR|Clostridium difficile|TetR
Because hydR is located in the erythromycin resistance element Tn5398 and is a regulatory gene, hydR may be related to erythromycin resistance.
>383|Q93TU7|Transcriptional repressor|Rhodococcus sp. NCIMB 9784|TetR
Because of its position, campR is situated in the gene cluster for the biodegradation of camphor genetic, and its organization, divergently from these genes, we can assign to CampR a hypothetical regulatory function in the expression of genes implicated in the biodegradation of camphor.
>387|Q46985|Regulator of the 4HPA-hydroxylase operon|Escherichia coli|AraC
Transcriptional regulator of the 4-hydroxyphenylacetate 3-monooxygenase operon hpaBC.
>388|Q47074|BfpT protein|Escherichia coli|AraC
BfpT activates bfpA (bundle-forming pilus A) and possibly eaeA.
>392|Q51543|PobR protein|Pseudomonas aeruginosa|AraC
Probable transcriptional activator of pobA, which encodes the p-hydroxybenzoate hydroxylase.
>393|Q51597|Cam repressor|Pseudomonas putida|TetR
CamR represses the expression of the operon camDCAB, and the expression of camR is autoregulated.
>405|Q56153|JadR2|Streptomyces venezuelae|TetR
JadR2 represses the biosynthesis of jadomycin B and seems to control cellular pigmentation.
It seems that jadR2 exerts its regulator role repressing the expression of jadR1 the positive regulator of the genes for jadomycin biosynthesis.
>407|Q56790|HrpXv|Xanthomonas campestris pv. vesicatoria|AraC
HrpXc is a hypersensitive-pathogenicity regulatory protein.
>408|Q56801|Hrp protein (Fragment)|Xanthomonas campestris|AraC
HrpXc is a hypersensitive-pathogenicity regulatory protein.
>409|Q56831|Hrp protein (Fragment)|Xanthomonas oryzae|AraC
The hrp system is a type III secretory system which is important in Xanthomonas oryzae pathogenicity on rice. The hrpXo protein contains a consensus domain for possible protein myristoylation whose consequence may result in a loss of recognition by host defence and surveillance systems.
>416|Q60011|Virginiae butanolide receptor|Streptomyces virginiae|TetR
BarA is the receptor protein for the butyrolactones autoregulators named virginiae butanolides (VBs) that control virginiamycin production in Streptomyces virginiae.
BarA acts repressing the transcription of the barB gene in absence of the VB autoinducer, being the first step in the signal transduction pathway of the autoinduce VB leading finally to virginiamycin production.
The VB autoinducer-BarA system regultes the coordinate production of two structurally different compounds, virginiamycin M1 (VM1) and virginiamycin S (VS), a pair of antibiotics that show strong synergistyc bactericidal activity.
>840|Q9AIQ9|IcaR|Staphylococcus caprae|TetR
IcaR is a repressor of the operon ica.
>841|Q9AIU0|Regulatory protein TtgR|Pseudomonas putida|TetR
TtgR is a transcriptional repressor of the ttgABC efflux pump operon.
TtgABC efflux pump is involved in both organic solvent tolerance and multiple antibiotic resistance of Pseudomonas putida DOT-T1E.
>842|Q9AJ68|Putative transcriptional repressor ButR|Streptomyces cinnamonensis|TetR
It is not known if butR plays a role in controlling ccr gene expression.
>844|Q9AJL5|VarR|Streptomyces virginiae|TetR
VarR is a trancriptional repressor which controls transcription of the varS-varR operon dependent on the antibiotic virginiamycin S (VS).
>851|Q9AMH9|Putative repressor simReg2 (Sim16)|Streptomyces antibioticus|TetR
The fact that simReg2 is transcribed divergently from simEx1 enables the possibility that SimReg2 to repress the expression of simEx1.
>852|Q9ANS7|LuxT|Vibrio harveyi|TetR
LuxT is a repressor of the luxO expression.
LuxT appears to be a general rather than lux-specific regulator.
>862|Q9EVJ6|Repressor protein MphR(A)|Escherichia coli|TetR
MphR(A) represses the transcription of the operon mph(A)-mrx-mphR(A).
The mph(A)and mrx genes confer a high level of resistance to erythromycin.
>866|Q9F0Y2|Pip|Streptomyces coelicolor|TetR
Pip is a pristinamycin I-induced transcriptional regulator protein detected in many Streptomyces species by its ability to specifically bind sequence motifs within the promoter of a Streptomyces pristinaespiralis mutidrug resistance gene (ptr).
In Streptomyces coelicolor, Pip seems to control the expression of the  transcriptionally coupled genes pep and pip by binding to two regulatory Pip binding motifs uptream of pep.
>879|Q9F6W0|CasR|Rhizobium etli|TetR
The gene casR encodes a protein that represses the expression of the casA gene.
>892|Q9F9Z7|PhaD (Fragment)|Pseudomonas resinovorans|TetR
By sequence similarity PhaD is a transcriptional regulator belonging to TetR family.
PhaD is an important constituent of polyhydroxyalkanoate (PHA) biosynthesis that seems to act preventing expression or binding of major granule proteins, like PhaI.
>893|Q9FA56|Putative regulator (Fragment)|Azoarcus evansii|TetR
PaaR may act as a regulator of the expression of the paa genes.
The paa genes are responsible for the aerobic phenylacetic acid catabolic pathway.
>895|Q9JRN1|Putative xylose operon regulatory protein|Actinobacillus actinomycetemcomitans|AraC
Putative xylose operon regulatory protein.
>898|Q9K5A5|RamA protein|Enterobacter aerogenes|AraC
By similarity to RamA of Klebsiella pneumoniae this protein is probably a transcriptional activator that confers a multidrug-resistance phenotype.
>899|Q9K5A7|MarA protein|Enterobacter aerogenes|AraC
By similarity with MarA of Escherichia coli it is probable that this protein controls expression of multiple chromosomal genes affecting resistance to antibiotics, organic solvents, oxidative stress agents, disinfectant products and other environmental hazards.
>901|Q9KH30|Regulatory protein HrpX|Xanthomonas oryzae pv. oryzicola|AraC
HrpX is a hypersensitivity-pathogenicity regulatory protein.
>903|Q9KIH5|Putative regulator|Rhizobium etli|TetR
RmrR is a putative repressor that controls the expression of the rmrAB efflux pump.
>906|Q9KJC4|ArpR|Pseudomonas putida|TetR
ArpR seems to be a repressor of the expression of the arpABC operon.
ArpABC in Pseudomonas putida S12 seems to be involved in multidrug resistance and not in tolerance towards organic solvents.
>918|Q9L6K7|Putative activator protein SefR|Salmonella enteritidis|AraC
SefR activates the transcription of the sef operon which encodes structural genes for translocation and biogenesis of SEF14 fimbriae.
>921|Q9L7Y6|BenR|Pseudomonas putida|AraC
BenR acts as an activator of benzoate degradation via the ortho ring fission, as an activator of benzoate and methylbenzoate degradation via the meta ring fission of the TOL plasmid and as repressor of 4-hydroxybenzoate degradation.
BenR has the effect of shutting down the cells' ability of to take up 4-hydroxybenzoate from their environment when benzoate is present. This provides a mechanism for the preferential degradation of benzoate by P. putida.
>923|Q9L8G8|SmcR (VvpR)|Vibrio vulnificus|TetR
ScmR appears to play an important role in starvation adaptation and in the regulation of many phase-regulated genes, including some virulence factors.
SmcR is involved in the regulation of starvation survival and the SIMC response.
ScmR acts as a repressor of protease expression during exponential growth.
ScmR represses motility, fimbria production and biofilm production.
ScmR appears to be part of a quorum-sensing system similarly to LuxR from Vibrio harveyi or HapR from Vibrio cholerae.
>926|Q9LBV6|BarZ|Streptomyces virginiae|TetR
BarZ should be considered a homologue of BarB.
>927|Q9LCD4|HrpX protein (Fragment)|Xanthomonas campestris pv. zinniae|AraC
HrpX is a hypersensitivity-pathogenicity regulatory protein.
>928|Q9LCD5|HrpX protein (Fragment)|Xanthomonas campestris pv. zantedeschiae|AraC
HrpX is a hypersensitivity-pathogenicity regulatory protein.
>930|Q9LCD7|HrpX protein (Fragment)|Xanthomonas campestris pv. vitians|AraC
HrpX is a hypersensitivity-pathogenicity regulatory protein.
>932|Q9LCD9|HrpX protein (Fragment)|Xanthomonas pisi|AraC
HrpX is a hypersensitivity-pathogenicity regulatory protein.
>934|Q9LCE1|HrpX protein (Fragment)|Xanthomonas campestris pv. incanae|AraC
HrpX is a hypersensitivity-pathogenicity regulatory protein.
>935|Q9LCE2|HrpX protein (Fragment)|Xanthomonas campestris pv. carotae|AraC
HrpX is a hypersensitivity-pathogenicity regulatory protein.
>936|Q9LCE3|HrpX protein (Fragment)|Xanthomonas campestris pv. cannabis|AraC
HrpX is a hypersensitivity-pathogenicity regulatory protein.
>937|Q9LCE4|HrpX protein (Fragment)|Xanthomonas axonopodis pv. alfalfae|AraC
HrpX is a hypersensitivity-pathogenicity regulatory protein.
>938|Q9LCE5|HrpX protein (Fragment)|Xanthomonas axonopodis pv. glycines|AraC
HrpX is a hypersensitivity-pathogenicity regulatory protein.
>959|Q9R2F3|Xyls/AraC-type transcriptional activator|Acinetobacter sp. NCIMB9871|AraC
ChnR activates the transcription of chnB encoding the cyclohexanone monooxygenase.
This enzyme participates in the cyclohexanol degradation pathway.
>962|Q9R9T2|PobR protein|Pseudomonas putida|AraC
By similarity to PobR of Pseudomonas aeruginosa this protein is probably a transcriptional activator of pobA, which encodes the p-hydroxybenzoate hydroxylase.
>963|Q9R9T9|Efflux pump regulator SrpR|Pseudomonas putida|TetR
srpR forms a gene cluster with srpS and both are putative regulators of the solvent resistance-pump SrpABC.
>965|Q9RA03|Hypothetical repressor protein KstR|Rhodococcus erythropolis|TetR
KstR is a putative repressor of the kstD gene.
KstR may be involved, as regulator, in phytosterol degradation.
>966|Q9RAJ1|Inactive regulatory protein|Mycobacterium sp. GP1|TetR
The product of the gene dhaR is a repressor of the expression of the gene dhaA in other organisms such as Rhodococcus rhodochrous NCIMB13064. In contrast in Mycobacterium sp. strain GP1 the gene dhaR possesses a 12 nucleotides deletion that inactivates to the regulatory protein DhaR, leading to constitutive expression of the gene dhaA.
>982|Q9RP98|Regulatory protein|Streptomyces fradiae|TetR
UrdK is a regulatory protein that controls the transcription of urdJ, that encodes a putative export protein for urdamycin A.
>983|Q9RPK9|TarA|Streptomyces tendae|TetR
TarA is a hypothetical gamma-butyrolactone-binding protein.
TarA is involved in the regulation of nikkomicyn biosynthesis.
>985|Q9RPV2|HpaA|Salmonella enterica subsp. enterica serovar Dublin|AraC
By similarity to HpaA of Escherichia coli this protein probably regulates the 4-hydroxyphenylacetate 3-monooxygenase hpaBC operon.
>986|Q9RR48|Regulatory protein|Azotobacter chroococcum|AraC
By similarity to pobR of  Pseudomonas aeruginosa and BY proximity to pobA, this protein is probably a transcriptional activator of pobA, which encodes the p-hydroxybenzoate hydroxylase.
>988|Q9S166|AdpA|Streptomyces griseus|AraC
AdpA activates strR that activates transcription of most of the streptomycin biosynthetic genes. AdpA also activates an ECF sigma factor which is a member of the A-factor regulatory cascade and participates in mycelium formation.
>995|Q9WW32|MtrA|Neisseria gonorrhoeae|AraC
MtrA is a positive regulator of the mtr (multiple transferable resistance) operon which is responsible for resistance to diverse antimicrobial hydrophobic agents.
>998|Q9X421|Xylose regulatory protein|Lactococcus lactis subsp. lactis|AraC
The XylR protein is probably a transcriptional regulator of the xylose metabolism operon.
>1001|Q9X545|Tetracycline repressor protein TetR|Corynebacterium glutamicum|TetR
The pAG1 TetR, TetR(Z), probably regulates transcription of the tetracycline resistance determinant in plamid pAG1.
The tetracycline resistance determinant in plamid pAG1 consists of two genes, tetA(Z) and tetR(Z), wich are oriented with divergently polarity.
TetR is a tetracycline inducible regulator that represses the expression of both genes, tetR and tetA.
>1004|Q9X7I7|PobR regulator|Pseudomonas sp.|AraC
By similarity with PobR of Pseudomonas aeruginosa this protein is probably a transcriptional activator of pobA, which encodes the p-hydroxybenzoate hydroxylase.
>1006|Q9X959|Multiple antibiotic resistance A protein (MarA) (Fragment)|Salmonella enterica subsp. enterica serovar Dublin|AraC
By  similarity to MarA of Escherichia coli this protein probably controls the expression of multiple chromosome genes affecting  resistance to antibiotics, organic solvents, oxidative stress agents, disinfectant products and other environmental hazards.
>1007|Q9X960|Multiple antibiotic resistance A protein (MarA) (Fragment)|Salmonella enteritidis|AraC
By  similarity to MarA of Escherichia coli this protein probably controls the expression of multiple chromosome genes affecting resistance to antibiotics, organic solvents, oxidative stress agents, disinfectant products and other environmental hazards.
>1008|Q9X9I4|Yersiniabactin transcriptional regulator, YbtA|Yersinia enterocolitica|AraC
This protein probably regulates genes of the high-pathogenicity island (HPI) which mediates biosynthesis and uptake of the yersiniabactin siderophore and a mouse-lethal phenotype.
>1011|Q9XCC5|Hypothetical transcriptional regulator TylQ|Streptomyces fradiae|TetR
TylQ is the key element in the regulation of the tyl gene cluster.
TylQ is a transcriptional repressor that blocks tylosin biosynthesis by controlling expression of the activator tylR.
>1012|Q9XCC7|Gamma-butyrolactone receptor protein TylP|Streptomyces fradiae|TetR
tylP is a receptor for one o more gamma-butyrolactones.
tylP is a repressor of the tylosin production.
>1014|Q9XDF0|Putative transcriptional repressor|Streptomyces griseus subsp. griseus|TetR
Because of its position and sequence similarity NonG may be a transcriptional repressor from nonactin biosynthesis.
>1015|Q9XDP8|Transcriptional regulator|Acinetobacter calcoaceticus|AraC
By similarity this protein is potentially involved in response to alkylating agents.
>1020|Q9Z3Y6|PhbR|Pseudomonas sp. 61-3|AraC
PhbR is necessary for poly (3-hydroxybutyrate) biosynthesis in Pseudomonas.
PhbR is a transcriptional activator of phbBAC.
>1024|Q9Z601|RegN|Nostoc punctiforme PCC 73102|TetR
The regN gene encodes a protein that might interact with devR.
>1026|Q9ZB51|MsmR (Fragment)|Streptococcus pyogenes|AraC
By similarity MsmR could be a multiple sugar metabolism regulator.
>1033|Q9ZGB7|LanK|Streptomyces cyanogenus|TetR
Function can only be inferred from the similar tracts of genetic organization and sequences with the tetracenomycin and jadomycin B biosynthesis gene clusters, from Streptomyces glaucescens and Streptomyces venezuelae repectively. LanK is similar to TcmR (S. glaucescens) and to Jard2 (S. venezuelae). The gene adjacent to lank is lanJ whose product resembles hydrophobic proteins known as proton-dependent transporters of different drugs, similar to tcmA, the gene adjacent to tcmR.
A hypothetical regulatory model would involve LanK as a regulator of landomycin A resistance, repressing the expression of its adjacent and divergently oriented gene, lanJ.
>1368|O30507|Arginine regulatory protein (Transcriptional regulator ArgR) (ArgR regulatory protein)|Pseudomonas aeruginosa|AraC
ArgR functions in the control of expression of certain genes of arginine biosynthesis and catabolism.
>1369|O31249|Transcriptional regulator of XylS /AraC family (XylS/AraC family)|Acinetobacter sp. ADP1|AraC
AlkR is essential for growth on alkanes as the sole carbon sources.
>1383|O50285|OpaR|Vibrio parahaemolyticus|TetR
The product of opaR is a transcriptional regulator that controls the opaque colony morphology in Vibrio parahaemolyticus.
>1386|O52066|AlcR (Transcriptional regulator)|Bordetella pertussis|AraC
AlcR is involved in the regulation of Bordetella alcaligin biosynthesis and transport genes and it is required for the full expression of these genes.
>1417|O69097|HrpX protein|Xanthomonas axonopodis pv. citri|AraC
HrpXct is a hypersensitive-pathogenicity regulatory protein.
>1431|O86852|Gamma-butyrolactone binding protein|Streptomyces coelicolor|TetR
ScbR acts as the citoplasmic receptor that specifically binds the SCB1 gamma-butyrolactone.
The system ScbR/SCB1 controls the production of actinorhodin and undecylprodigiosin, the two pigmented antibitics made by Streptomyces coelicolor.
>2160|Q53901|ActII protein (Putative transcriptional regulatory protein)|Streptomyces coelicolor|TetR
actII-1 gene product represses the expression of the actII-2 actII-3 operon, that appears to be involved in actinorhodin export.
>2162|Q56951|AraC-like regulator YbtA (Transcriptional regulator YbtA)|Yersinia pestis|AraC
YbtA is a transcriptional activator for Psn and for the putative siderophore biosynthetic gene cluster.
>4196|Q9F8V9|TetR family bacterial regulatory protein|Agrobacterium tumefaciens|TetR
AmeR represses expression of the ameABC operon.
ameABC genes function as an efflux system in Agrobacterium tumefaciens.
>4308|Q9JN89|Hypothetical protein mmfR (Putative lactone-dependent transcriptional regulator (TetR-family), MmfR)|Streptomyces coelicolor|TetR
Because of sequence similarity and gene organization MmfR is an hypothetical gamma-butyrolactone receptor that represses expression of the gene mmfL and likely MmfR represses its own expression.
>4309|Q9JN93|Hypothetical protein mmyR (Putative lactone-dependent transcriptional regulator (TetR-family), MmyR)|Streptomyces coelicolor|TetR
Based on the localization of the mmyR gene encoding protein MmyR may be involved in the regulation of the methylomycin biosynthesis.
>4374|Q9KFT3|Methylphosphotriester-DNA alkyltransferase (AraC/XylS family) (EC 2.1.1.-)|Bacillus halodurans|AraC
AdaA is a methylphosphotriester-DNA-alkyltransferase.
>4379|Q9KKT2|Ada regulatory protein|Vibrio cholerae|AraC
By similarity to Ada of Escherichia coli this protein could be involved in the regulatory response to DNA damages.
>4453|Q9RIP5|DNA-binding response regulator|Streptococcus pneumoniae|AraC
The RR07 protein is the response regulator of a two-component signal transduction system (TCS). In bacteria, adaptive responses to environmental stimuli are often initiated by two-component signal transduction systems. The prototypical TCS comprises two proteins: a histidine kinase (HK) and a response regulator (RR).
>4533|Q9XA73|Putative araC-family transcriptional regulator|Streptomyces coelicolor|AraC
By similarity to ArgR this protein could control arginine biosynthesis and catabolism.
>4541|Q9ZBF2|Putative ADA-like regulatory protein|Streptomyces coelicolor|AraC
By similarity this protein functions as an Ada-like regulatory protein.
>4544|Q9ZBT8|Putative ADA-like regulatory protein|Streptomyces coelicolor|AraC
By similarity this protein is involved in the regulating response to DNA damages.
>4834|16131152|putative transcriptional regulator|Escherichia coli K12|TetR
EnvR seems to be a transcriptional repressor of the acrEF operon (formerly envCD).
The acrEF operon encodes the components of an efflux pump.
>4926|16077337|transcriptional regulator|Bacillus subtilis subsp. subtilis str. 168|TetR
LmrA is a regulator of the lmrAB operon that controls linkomycin resistance.
>5056|15597216|probable transcriptional regulator|Pseudomonas aeruginosa PAO1|TetR
AmrR represses the expression of amrAB genes, that encodes the AmrAB pump contributing to the intrinsic resistance of this organism to aminoglycosides.
>5116|15600252|probable transcriptional regulator|Pseudomonas aeruginosa PAO1|TetR
By sequence similarity PhaD is a transcriptional regulator belonging to TetR family.
PhaD is important for polyhydroxyalkanoate (PHA) biosynthesis because it seems to act preventing expression or binding of major granule proteins, like PhaI.
Bacterial polyhydroxyalkanoates (PHAs) are polyesters of 2-, 3-, 4-, 5-, 6-hydroxyacids produced as intracellular granules by a large variety of bacteria as carbon and energy storage material if a carbon source is provided in excess and if another nutrient, such as nitrogen, sulfur, phosphate, iron, magnesium, potassium or oxygen is limiting.
>5460|15928251|ica operon transcriptional regulator IcaR|Staphylococcus aureus subsp. aureus N315|TetR
IcaR represses the expression of the ica operon.
The ica operon is required for biofilm formation in S. aureus.
>6026|26991683|transcriptional regulator, TetR family|Pseudomonas putida KT2440|TetR
By sequence similarity PhaD is a transcriptional regulator belonging to TetR family.
PhaD is important for polyhydroxyalkanoate (PHA) biosynthesis that seems to act preventing expression or binding of major granule proteins, like PhaI.
Bacterial polyhydroxyalkanoates (PHAs) are polyesters of 2-, 3-, 4-, 5-, 6-hydroxyacids produced as intracellular granules by a large variety of bacteria as carbon and energy storage material if a carbon source is provided in excess and if another nutrient, such as nitrogen, sulfur, phosphate, iron, magnesium, potassium or oxygen is limiting.
>6853|19552090|transcriptional regulator|Corynebacterium glutamicum ATCC 13032|TetR
AmtR is a global repressor in the nitrogen regulation system.
AmtR represses the expression of the amt gene.
AmtR also regulates transcription of the amtB-glnK-glnD operon.
>6871|19554126|transcriptional regulator|Corynebacterium glutamicum ATCC 13032|TetR
McbR is involved in the regulation of the metabolic network, directing the synthesis of L-methionine in Corynebacterium glutamicum.
McbR, in absence of L-methionine, represses the expression of six key enzymes for the biosynthesis of the sulfur containing amino acids L-cysteine and L-methionine including sulfonate utilization and sulfite reduction.
>7054|21224401|A-factor receptor homolog|Streptomyces coelicolor A3(2)|TetR
The gene crpB encodes an ArpA-like protein, that behaves as a negative regulator in the production of antibiotics actinorhodin and undecylprodigiosin and morphogenesis.
>7064|21224630|transcriptional regulator|Streptomyces coelicolor A3(2)|TetR
The gene crpA encodes an ArpA-like protein, that seems to act, directly or indirectly, as a positive regulator or an accelerator for the production of antibiotics actinorhodin and undecylprodigiosin and morphogenesis.
>7937|28872258|transcriptional regulator PhaD|Pseudomonas syringae pv. tomato str. DC3000|TetR
By sequence similarity PhaD is a transcriptional regulator belonging to TetR family.
PhaD is important for polyhydroxyalkanoate (PHA) biosynthesis that seems to act preventing expression or binding of major granule proteins, like PhaI.
Bacterial polyhydroxyalkanoates (PHAs) are polyesters of 2-, 3-, 4-, 5-, 6-hydroxyacids produced as intracellular granules by a large variety of bacteria as carbon and energy storage material if a carbon source is provided in excess and if another nutrient, such as nitrogen, sulfur, phosphate, iron, magnesium, potassium or oxygen is limiting.
>9416|O24741|FarA|Streptomyces sp. FRI-5|TetR
FarA is the IM-2 specific receptor.
FarA in conjunction with IM-2 play an important role in the regulation of secondary metabolism in Streptomyces lavendulae. While the production of nucleoside antibiotics showdomycin and minimycin is induced by addition of IM-2, the production of antituberculosis antibiotic D-cycloserine is ended.
FarA acts as a negative transcriptional regulator for the biosynthesis of nucleoside antibiotics and a blue pigment in Streptomyces lavendulae FRI-5, switching on their expression in presence of IM-2.
FarA acts as an positive transcriptional regulator for the biosynthesis of D-cycloserine in Streptomyces lavendulae FRI-5, switching off its expression in presence of IM-2.
FarA affects growth characteristics in liquid culture.
The IM-2/FarA system does not play a significant role in the morphological differentiation of Streptomyces lavandulae FRI-5.
FarA is necessary for IM-2 biosynthesis.
>9417|P13225|Virulence regulon transcriptional activator virF|Yersinia enterocolitica|AraC
VirF is a positive transcriptional regulatory protein of the virulence yop,  yadA and ysc genes of the virulence plasmid pYV.